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  Ivan A. Vorobjev
Head of the laboratory, Senior Research Fellow, Dr Sci, professor

phone (095)939-2084
fax (095)939-3181

ivorobjev@mail.ru
 
  Research interests
Cytoskeleton and cell motility

Education and Professional Experience

1970-1975 Undegraduate student, Biological Faculty, Moscow State University
1975-1978 Graduate student, Biological Faculty, Moscow State University
1978-present research associate, researcher, senior research fellow, head of laboratoty at A.N.Belozersky Institute, Moscow State University

1979 Ph.D. in Cytology

1989 Doctorate of Science in Cytology

1992 - visiting researcher at Beckman Laser Institute (University of California, Irvine, CA)

1999-present professor at Dept. Cytology and Histology, Biological Faculty, Moscow State University

Publications

Smurova KM, Alieva IB, Vorob'ev IA.
Free and centrosome-attached microtubules: quantitative analysis and themodeling of two-component system.
Tsitologiia. 2007;49(4):270-9. Russian.
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Mimori-Kiyosue Y, Grigoriev I, Sasaki H, Matsui C, Akhmanova A, Tsukita S, Vorobjev I.
Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.
Genes Cells. 2006 Aug;11(8):845-57.
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Grigoriev I, Borisy G, Vorobjev I.
Regulation of microtubule dynamics in 3T3 fibroblasts by Rho family GTPases.
Cell Motil Cytoskeleton. 2006 Jan;63(1):29-40.
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Dobrinskikh EA, Vorob'ev IA.
Microtubules are necessary for lamellae retraction of Vero cells.
Tsitologiia. 2006;48(11):906-17. Russian.


Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, Sasaki H, Matsui C, Severin F, Galjart N, Grosveld F, Vorobjev I, Tsukita S, Akhmanova A.
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.
J Cell Biol. 2005 Jan 3;168(1):141-53.
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Alieva I B, Vorobjev I A.
Vertebrate primary cilia: a sensory part of centrosomal complex in tissue cells, but a "sleeping beauty" in cultured cells?
Cell Biol Int. 2004;28(2):139-50.
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Vorobjev I A, Alieva I B, Grigoriev I S, Borisy G G.
Microtubule dynamics in living cells: direct analysis in the internal cytoplasm.
Cell Biol Int. 2003;27(3):293-4.
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Vorob'ev IA, Grigor'ev IS.
Dynamics and the life cycle of cell microtubules
Tsitol Genet. 2003 Mar-Apr;37(2):22-38. Review. Russian.
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Y. A. Komarova, I. A. Vorobjev and G.G. Borisy
Life cycle of MTs: persistent growth in the cell interior, asymmetric transition frequencies and effects of the cell boundary.
J. Cell Sci. 2002 115: 3527-3539
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Vorobjev I, Malikov V, Rodionov V.
Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules.
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10160-5.
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Chernobel'skaia OA, Grigor'ev IS, Alieva IB, Vorob'ev IA. Evaluation of various methods of measurement of the microtubule length in the cytoplasm of cultured cells. Ontogenez. 2001 Jan-Feb;32(1):58-66. Russian.
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Vorobjev IA, Uzbekov RE, Komarova YuA, Alieva IB.
Gamma-tubulin distribution in interphase and mitotic cells upon stabilization and depolymerization of microtubules.
Membr Cell Biol. 2000;14(2):219-35.
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Alieva IB, Vorobjev IA.
Interphase microtubules in cultured cells: long or short? Membr Cell Biol. 2000;14(1):57-67.
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Vorob'ev IA, Grigor'ev IS, Borisy GG.
Microtubule dynamics in cultured cells. Ontogenez. 2000 Nov-Dec;31(6):420-8. Russian.
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Grigoriev IS, Chernobelskaya AA, Vorobjev IA.
Nocodazole, vinblastine and taxol at low concentrations affect fibroblast locomotion and saltatory movements of organelles.
Membr Cell Biol. 1999;13(1):23-48.
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Alieva IB, Gorgidze LA, Komarova YA, Chernobelskaya OA, Vorobjev IA.
Experimental model for studying the primary cilia in tissue culture cells. Membr Cell Biol. 1999;12(6):895-905.
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Neverova AL, Uzbekov RE, Votchal MS, Zatsepina OV, Vorobjev IA.
Postmitotic reconstruction of nucleoli in culture cells with UV-microbeam photoinactivated centrosome.
Membr Cell Biol. 1999;12(6):805-15.
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Vorobjev IA, Rodionov VI, Maly IV, Borisy GG.
Contribution of plus and minus end pathways to microtubule turnover. J Cell Sci. 1999 Jul;112 ( Pt 14):2277-89.
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Alieva IB, Vorob'ev IA.
The effect of the increase in the calcium concentration induced by action of the ionophore A-23187 on mitosis in cultured ESK cells. Tsitologiia. 1996;38(12):1261-8. Russian.
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Gorgidze LA, Oshemkova SA, Vorobjev IA.
Blue light inhibits mitosis in tissue culture cells. Biosci Rep. 1998 Aug;18(4):215-24.
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Vorobjev IA, Svitkina TM, Borisy GG.
Cytoplasmic assembly of microtubules in cultured cells. J Cell Sci. 1997 Nov;110 ( Pt 21):2635-45.
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Komarova YuA, Ryabov EV, Alieva IB, Uzbekov RE, Uzbekova SV, Vorobjev LA.
Polyclonal antibodies against human gamma-tubulin stain centrioles in mammalian cells from different tissues.
Membr Cell Biol. 1997;10(5):503-13.
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Alieva IB, Vorobjev IA.
Stereoscopic analysis of microtubule pattern around the centrosome in interphase PK cells after treatment with taxol and nocodazole.
Membr Cell Biol. 1997;11(1):17-29.
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Grigoriev IS, Chernobelskaya AA, Vorobjev IA.
Quantitative analysis of the movements of cytoplasmic granules in polarized fibroblasts. Membr Cell Biol. 1997;11(2):195-211.
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Neverova AL, Uzbekov RE, Votchal MS, Vorob'ev IA.
The effect of ultraviolet microbeam irradiation of the centrosome on cellular behavior. IV. Synthetic activity, cell spreading and growth with an inactivated centrosome.
Tsitologiia. 1996;38(2):145-54. Russian.

Uzbekov RE, Vorob'ev IA.
Behavior of the mitotic apparatus after ultraviolet microirradiation of the spindle pole. Biofizika. 1996 Jan-Feb;41(1):153-8.
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Grigoriev IS, Chernobelskaya AA, Vorobjev IA.
Quantitative analysis of the movements of cytoplasmic granules in polarized fibroblasts. Membr Cell Biol. 1997;11(2):195-211.
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Alieva IB, Vorobjev IA.
Stereoscopic analysis of microtubule pattern around the centrosome in interphase PK cells after treatment with taxol and nocodazole. Membr Cell Biol. 1997;11(1):17-29.
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Uzbekov RE, Vorob'ev IA.
Behavior of the mitotic apparatus after ultraviolet microirradiation of the spindle pole. Biofizika. 1996 Jan-Feb;41(1):153-8. Russian.

Uzbekov RE, Votchal MS, Vorobjev IA.
Role of the centrosome in mitosis: UV micro-irradiation study. J Photochem Photobiol B. 1995 Aug;29(2-3):163-70.

Komarova IA, Vorob'ev IA.
The centrosome structure in enterocytes in the histogenesis of the mouse intestine. Ontogenez. 1995 Sep-Oct; 26(5):390-9. Russian.
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Gorgidze LA, Vorobjev IA.
Centrosome and microtubules behavior in the cytoplasts. J Submicrosc Cytol Pathol. 1995 Jul;27(3):381-9.
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Alieva IB, Vorobjev IA.
Centrosome behaviour and orientation of centrioles under the action of energy transfer inhibitors.
Cell Biol Int. 1995 Feb;19(2):103-12.
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Uzbekov RE, Votchal MS, Vorobjev IA.
Role of the centrosome in mitosis: UV micro-irradiation study. J Photochem Photobiol B. 1995 Aug;29(2-3):163-70.
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Speranskaia SR, Votchal MS, Vorob'ev IA.
Saltatory movements of the cytoplasmic granules in the cells of an ESK culture. Tsitologiia. 1995;37(8):783-90. Russian.

Alieva IB, Vorob'ev IA.
An analysis of centriolar orientation in cultured ESK cells under the action of the calcium ionophor A23187. Tsitologiia.
1995; 37(5-6):491-9. Russian.
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Alieva IB, Vorobjev IA.
Centrosome behavior under the action of a mitochondrial uncoupler and the effect of disruption of cytoskeleton elements on the uncoupler-induced alterations. J Struct Biol. 1994 Nov-Dec;113(3):217-24.
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Komarova IA, Vorob'ev IA.
The ultrastructure of the cell center in the enterocytes of mouse embryos andnewborn mice. Ontogenez. 1994 Mar-Apr;25(2):76-88. Russian.
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Gorgidze LA, Vorob'ev IA.
Centrioles can replicate in cultured cells in the absence of a nucleus. Tsitologiia. 1994;36(8):837-43. Russian.
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Vorobjev IA, Liang H, Wright WH, Berns MW.
Optical trapping for chromosome manipulation: a wavelength dependence of induced chromosome bridges. Biophys J. 1993 Feb;64(2):533-8.
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Komarova IA, Vorob'ev IA.
Ultrastructural changes in the cell center during enterocyte differentiation in the mouse. Tsitologiia. 1993;35(5):36-43. Russian.

Alieva IB, Nadezhdina ES, Vaisberg EA, Vorobjev IA.
Microtubule and intermediate filament patterns around the centrosome in interphase cells.
The Centrosome. 1992; 103-129
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Uzbekov RE, Vorob'ev IA.
The effect of the UV microirradiation of the centrosome on cell behavior. III. The ultrastructure of the centrosome after irradiation. Tsitologiia. 1992;34(2):62-7. Russian.
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Alieva IB, Vorob'ev IA.
A stereoscopic analysis of centrosome structure in the cells of a tissue culture under the action of energy metabolism inhibitors. I. 2,4-Dinitrophenol, deoxyglucose, sodium azide and the calcium ionophore A23187. Tsitologiia. 1992;34(5):65-75. Russian.
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Alieva IB, Vorob'ev IA.
A stereoscopic analysis of the centrosome structure in tissue culture cells under the action of carbonyl cyanide p-trifluoromethoxyphenylhydrazone and ouabain Tsitologiia. 1992;34(7):17-23. Russian.
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Gorgidze LA, Vorob'ev IA.
The ultrastructure of the centrosome in cytoplasts and its alteration under the action of ouabain. Tsitologiia. 1992;34(10):45-51. Russian.
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Alieva IB, Vorobjev IA.
Induction of multipolar mitoses in cultured cells: decay and restructuring of the mitotic apparatus and distribution of centrioles. Chromosoma. 1991 Sep;100(8):532-42.
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Uzbekov RE, Vorob'ev IA.
The effect of UV microirradiation of the centrosome on cell behavior. I. The destruction of the mitotic spindle and disruption of cell division during irradiation in the metaphase. Tsitologiia. 1991;33(2):15-22. Russian.
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Gorgidze LA, Oshemkova SA, Vorob'ev IA.
The inhibition of mitosis in tissue culture cells by blue light. Tsitologiia. 1991;33(1):50-6. Russian.

Uzbekov RE, Vorob'ev IA.
The effect of centrosome UV microbeam irradiation on cell behavior. II. The radiation sequelae in the anaphase: the completion of division and the fate of the interphase cell. Tsitologiia. 1991;33(10):79-84. Russian.
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Alieva IB, Vorob'ev IA.
The effect of the disruption of the cytoskeletal elements on uncoupler-induced changes in the centrosome. Tsitologiia. 1990;32(6):620-5. Russian.
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Alieva IB, Vorob'ev IA.
The centrosome reaction in tissue-culture cells to depolarization of the cell membranes. Nauchnye Doki Vyss Shkoly Biol Nauki. 1990;(4):45-52. Russian.

Alieva IB, Vorob'ev IA.
Morphofunctional characteristics of the striated centrosome rootlets of cultured embryonic pig kidney cells. Tsitologiia. 1989 Sep;31(9):1016-9. Russian.
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Uzbekov RE, Vorob'ev IA, Drachev VA.
The effect of the laser microirradiation of the cell center on neutrophil motility. Tsitologiia. 1989 Aug;31(8):874-81. Russian.
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Alieva IB, Vorob'ev IA.
Cellular behavior and centriole distribution during multipolar mitosis induced by nocodazole action.
Tsitologiia. 1989 Jun;31(6):633-41. Russian.
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Alieva IB, Vorob'ev IA.
Reaction of the cell center to exposure to the calcium ionophore A-23187. Tsitologiia. 1989 Mar;31(3):259-66. Russian.

Vorob'ev IA, Drachev VA.
The effect of high hydrostatic pressure on the cell center and microtubules in tissue culture cells.
Tsitologiia. 1989 Feb;31(2):170-5. Russian.
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Alieva IB, Vorob'ev IA.
Centrosome behavior in the exposure of tissue culture cells to energy metabolism inhibitors.
Nauchnye Doki Vyss Shkoly Biol Nauki. 1989;(6):45-9. Russian.

Alieva IB, Vorob'ev IA, Chentsov YuS.
Stereoscopic analysis of the arrangement of microtubules around the centrosome in a tissue culture.
Dokl Akad Nauk SSSR. 1989;305(5):1232-4. Russian.

Gudima GO, Vorobjev IA, Chentsov YuS.
Centriolar location during blood cell spreading and motion in vitro: an ultrastructural analysis.
J Cell Sci. 1988 Feb;89 ( Pt 2):225-41.

Vasil'ev NB, Vorob'ev IA, Leontovich AM, Petrovskaia MB.
An analysis of the centriole orientation in tissue culture cells. Tsitologiia. 1988 Sep;30(9):1091-100. Russian.

Vorobjev IA, Nadezhdina ES.
The centrosome and its role in the organization of microtubules. Int Rev Cytol. 1987;106:227-93. Review.

Vorob'ev IA, Chentsov YS.
Centrioles in the cell cycle of L cells. Ontogenez. 1987 Sep-Oct;18(5):478-83. Russian.

Alieva IB, Vorob'ev IA.
Conditions of the reversibility of metaphase arrest and induction of multi-polar mitoses after treatment with nocodazole. Tsitologiia. 1987 May;29(5):560-8. Russian.

Gudima GO, Vorob'ev IA, Chentsov YS.
Behavior of the cell center during epithelial cell spreading. Tsitologiia. 1986 Jun;28(6):576-81. Russian.
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Vorob'ev IA, Chentsov YS.
Centrioles and microtubules in interphase cells exposed to colcemid. The concentration- and time-dependent effect of the action of the poison. Tsitologiia. 1985 Oct;27(10):1101-5. Russian.
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Gudima GO, Vorob'ev IA, Chentsov YS.
Cell center of macrophages, granulocytes and lymphocytes during in vitro cell spreading, polarization and movement. Tsitologiia. 1984 Sep;26(9):1002-7. Russian.

Nadezhdina ES, Vorob'ev IA.
Deformation and displacement of the mitotic spindle during centrifugation of live cells block mitosis. Dokl Akad Nauk SSSR. 1984;276(4):965-8. Russian.

Gudima GO, Vorob'ev IA, Chentsov YS.
Structural change in the cell center during fibroblast polarization and movement. Tsitologiia. 1983 Aug;25(8):883-8. Review. Russian.

Vorobjev IA, Zorov DB.
Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum.
FEBS Lett. 1983 Nov 14;163(2):311-4.

Vorobjev IA, Chentsov YS.
The dynamics of reconstitution of microtubules around the cell center after cooling. Eur J Cell Biol. 1983 May;30(2):149-53.
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Gudima GO, Vorob'ev IA, Chentsov YS.
Behavior of the cell center in the distribution of fibroblasts. Nauchnye Doki Vyss Shkoly Biol Nauki. 1983;(7):45-50. Russian.

Vorobjev IA, Chentsov YuS.
Centrioles in the cell cycle. I. Epithelial cells. J Cell Biol. 1982 Jun;93(3):938-49.

Vorob'ev IA, Chentsov YS.
Dynamics of microtubule reconstitution around the cell center in cultured cells after cooling.
Tsitologiia. 1982 Nov;24(11):1286-90. Russian.
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Chentsov YS, Vorob'ev IA, Nadezhdina ES.
Simple method of detecting the centrioles and cytoskeleton in tissue culture cells by light microscopy.
Tsitologiia. 1982 Mar;24(3):243-7. Russian.
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Vorobjev IA, Chentsov YS.
The ultrastructure of centriole in mammalian tissue culture cells.
Cell Biol Int Rep. 1980 Nov;4(11):1037-44.

Vorob'ev IA, Chentsov YS.
Centrioles in the cell cycle. I. Ultrastructure and orientation of centrioles during the second half of mitosis. Nauchnye Doki Vyss Shkoly Biol Nauki. 1978;(9):65-71. Russian.

Vorob'ev IA, Chentsov YS.
Centrioles in the cellular cycle. II. The interphase and 1st half of mitosis. Nauchnye Doki Vyss Shkoly Biol Nauki. 1978;(11):54-64. Russian.